Rotavirus, the leading cause of severe acute diarrhoea in infants and young children worldwide, remains a major public health challenge in West Africa. In settings where vaccines are not yet available, rotavirus accounts for up to 60% of severe acute diarrhoeal disease in children under five, often leading to preventable hospitalizations and deaths. Tackling this silent killer requires not only vaccines but also strong surveillance systems, quality laboratory testing and cross-country collaboration.