The Ebola outbreak that erupted in Guinea in early 2021 was declared over on 19 June, just four months after the first cases were confirmed in a rural community in the south of the country. Banking on the lessons learned from the deadly 2014–2016 outbreak as well as a growing national expertise, a prompt response was mounted, helping to curb widespread infection. Minister of Health Honourable Dr Rémy Lamah explains what it took to halt the virus and the challenges met.