- Multisectoral One Health approach: supports Member States through a sustained multisectoral and multidisciplinary One Health approach, and integrates AMR into climate, food safety, health systems and health security agendas.
- Technical guidance and stewardship: develops and applies technical guidance and tools, mainstreams AMR within primary health care, and scales up antimicrobial stewardship through updated guidelines and regulatory enforcement.
- Surveillance and data systems: strengthens surveillance and data systems and supports enrolment in the Global Antimicrobial Resistance and Use Surveillance System (GLASS) so that countries report and use data for decision-making.
- Monitoring, evaluation and accountability: strengthens AMR monitoring, evaluation and regular reporting to ensure accountability, including through the Global Database for Tracking Antimicrobial Resistance (AMR) Country Self-Assessment Survey (TrACSS).
- Awareness and responsible use: promotes awareness and responsible use of antimicrobials, including nationwide awareness campaigns involving different sectors.
- Research and innovation: advances research and innovation on AMR.
- Capacity and financing: builds national and regional capacity, and supports increased domestic investment and the mobilization of external financing to accelerate implementation of national AMR action plans.
- Alignment with global and regional frameworks: anchors action in the Regional strategy for expediting the implementation and monitoring of national action plans (NAPs) on AMR and the UNGA Political Declaration on Antimicrobial Resistance from the 2024 High-Level Meeting.