Antimicrobial resistance (AMR) remains a critical global health threat, driven primarily by the misuse and overuse of antimicrobials in human health, animal health and agriculture, as well as by anthropogenic activities that result in the contamination and pollution of the environment.

The burden weighs heavily on the WHO African Region, where Sub-Saharan Africa experienced the highest mortality rates. Member States have nonetheless made commendable strides in advancing the implementation of their national AMR action plans, with nearly all engaging in core areas such as surveillance, stewardship, infection prevention and control (IPC), and policy development.

WHO supports Member States to combat AMR through a sustained multisectoral One Health approach: developing and applying technical guidance and tools, strengthening surveillance and data systems, promoting awareness and responsible use, advancing research and innovation, and building national and regional capacity for a comprehensive and sustained response.