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In the African Region, oral diseases are among the most common noncommunicable diseases (NCDs) and may affect people throughout their lifetime, causing pain, disfigurement, social isolation, distress and even death. This strategy focuses on four objectives and aims to achieve five oral health targets in realizing effective prevention and control of oral diseases in the WHO African Region. The document contains a set of priority actions that include enhancing advocacy, leadership and multisectoral action, reducing common risk factors, strengthening health systems, improving integrated oral health surveillance and measurement of progress, as well as conducting research related to oral diseases.