Polio, a disease targeted for eradication, has been a persistent focus for South Africa. In 2006, South Africa proudly received its polio-free certification, a significant milestone. However, in 2017, this status was rescinded, only to be regained in 2019. The entire African continent achieved Polio Free Certification in 2020. Nevertheless, the unforeseen challenges posed by the COVID-19 pandemic compromised vaccination efforts, leading to a resurgence of vaccine-preventable diseases (VPDs), including polio, in Southern Africa.