South Africa's multisectoral response to the Cholera Outbreak has culminated in successful containment within 165 days of the cholera outbreak official declaration. The initial cases were reported in Gauteng, with both patients having a history of travel to a neighboring country grappling with a cholera outbreak. Subsequently, the outbreak rapidly spread, affecting 17 out of 52 districts across five provinces, including Gauteng, Free State, Mpumalanga, North-West, and Limpopo.