The Ministry of Health of South Sudan with support from WHO conducted a five days planning workshop as a precursor for a detailed Vulnerability, Risk Assessment and Mapping (VRAM) exercise. In 2017, South Sudan held a Joint External Evaluation (JEE) of IHR core capacities (2005) which indicated limited capacities for preparedness and response to Public Health hazards. South Sudan is among the countries in the region that are prone to disasters or emergencies that can have a significant impact on the population and the health systems. Infectious diseases continue to pose a major public health threat in South Sudan. Adding to the chronic disease burden, regular outbreaks further threaten people's health.